It stimulates what have been described as “oneirogenic” effects, meaning that it generates a waking dream state. These effects have been described as very similar to dream-like visions in both quality and content.
The therapeutic doses of ibogaine that we use in the detoxification process may last as long as 24-48 hours. Everybody’s individual experience is unique, however there are some common elements that many people share. What seems most common is that the experience is profoundly meaningful. And that it is healing and beneficial and healing on all levels of the body and psyche.
As ibogaine passes through the blood stream the liver begins to convert it into a metabolite called nor-ibogaine. Nor-ibogaine is said to have many similar effects to ibogaine, but it has a much longer half-life in the body. Researchers estimate that nor-ibogaine can remain in the body for a period of days to weeks after the treatment. May also be at least partially responsible for the long-term reduction in cravings that follow.
Another noticeable long-term effect is that ibogaine therapy stimulates the secretion of glial cell derived neurotrophic factor, or GDNF, which is a protein that generates the growth of new dopamine neurons. The effects of GDNF are so pronounced in their repair of the dopamine system that ibogaine has shown promise as a potential therapy for Parkinson’s disease. The same dopamine repair is notable for addiction detox because the growth of new dopamine neurons provides an opportunity to repair and rewire the brain’s desire and reward system.